There have been major improvements regarding therapeutic treatments for various human medical diseases. This includes gene therapy, several anti cancer treatments and now clodronate liposome. Indeed, the latter have showed promising results that might help on the treatment of various autoimmune diseases, prevention of transplantation rejection and most importantly, cancer.
Apart from cardiovascular and metabolic diseases, autoimmune diseases and cancer are among the common medical condition of people through out the world. What's worse is that both diseases remains to be incurable as all present therapies focuses on how to slow down the progression or worsening of the disease.
It activates the process of T and B lymphocytes, meaning they are the ones that can activate the immune system to work. Such phenomenon though is a good thing as it defends human from getting sick such as flu or any another viral diseases. But, this could also be a bad thing especially to those that have autoimmune diseases or to people that just had a transplant operation.
In normal circumstances, this process makes the body cope up with simple diseases such as colds or cough, thus the term healthy immune system. However, a damage to the immune system could make it passive or overly active. An overly active immune system will result to autoimmune diseases, wherein your own immune cells are attacking your own cells causing several medical disorders.
Indeed, the macrophage cells are termed to be the most important factor in the immune system. Such cells attack bacteria or virus through phagocytosis. Phagocytosis is the ingesting and digesting of bacteria and other cells which are foreign to the body. Phagocytosis is the process that actively defends the body every single day and whenever one is exposed to active viruses.
Therefore liposomes acts as a vehicle to effectively carry clodronate inside the body and towards the cells without destroying its composition. After injecting the solution, the macrophage will then automatically identifies the substance to be foreign hence engulfing it. As soon as the macrophage ingest and digest the liposome, the main component of the drug will be released intracellularly.
After injection of the liposome containing the active component, macrophages will identify such component as foreign hence activating phagocytosis. As soon as the liposome is engulfed by the phagocyte, it will release the active component, clodronate inside then inducing apoptosis. Apoptosis is a process that cause cell death.
As soon as the active component is released inside the macrophage cell, it will cause apoptosis, or in other words, cell death. With the death of macrophage cells, this will suppress the immune system. This is why, such component has shown promising results towards reducing disease progression of patients with autoimmune disease as well as prevent transplant rejection.
Several research conclusions have made clodronate liposome a promising therapeutic agent for humans affected with cancer and autoimmune diseases. Such component was said to have a significant role in cardiovascular diseases as well and that includes myocardial infarction.
Apart from cardiovascular and metabolic diseases, autoimmune diseases and cancer are among the common medical condition of people through out the world. What's worse is that both diseases remains to be incurable as all present therapies focuses on how to slow down the progression or worsening of the disease.
It activates the process of T and B lymphocytes, meaning they are the ones that can activate the immune system to work. Such phenomenon though is a good thing as it defends human from getting sick such as flu or any another viral diseases. But, this could also be a bad thing especially to those that have autoimmune diseases or to people that just had a transplant operation.
In normal circumstances, this process makes the body cope up with simple diseases such as colds or cough, thus the term healthy immune system. However, a damage to the immune system could make it passive or overly active. An overly active immune system will result to autoimmune diseases, wherein your own immune cells are attacking your own cells causing several medical disorders.
Indeed, the macrophage cells are termed to be the most important factor in the immune system. Such cells attack bacteria or virus through phagocytosis. Phagocytosis is the ingesting and digesting of bacteria and other cells which are foreign to the body. Phagocytosis is the process that actively defends the body every single day and whenever one is exposed to active viruses.
Therefore liposomes acts as a vehicle to effectively carry clodronate inside the body and towards the cells without destroying its composition. After injecting the solution, the macrophage will then automatically identifies the substance to be foreign hence engulfing it. As soon as the macrophage ingest and digest the liposome, the main component of the drug will be released intracellularly.
After injection of the liposome containing the active component, macrophages will identify such component as foreign hence activating phagocytosis. As soon as the liposome is engulfed by the phagocyte, it will release the active component, clodronate inside then inducing apoptosis. Apoptosis is a process that cause cell death.
As soon as the active component is released inside the macrophage cell, it will cause apoptosis, or in other words, cell death. With the death of macrophage cells, this will suppress the immune system. This is why, such component has shown promising results towards reducing disease progression of patients with autoimmune disease as well as prevent transplant rejection.
Several research conclusions have made clodronate liposome a promising therapeutic agent for humans affected with cancer and autoimmune diseases. Such component was said to have a significant role in cardiovascular diseases as well and that includes myocardial infarction.
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